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Publications

The ODPRN has been publishing peer-reviewed papers on findings from their rapid response research since 2008. Publications span multiple topics, and are typically freely accessible (i.e. open-access).

Publications are listed below in chronological order. You can also sort publications by year and topic.

Title Year Category Additional Resources
Self-Monitoring of Blood Glucose: Impact of Quantity Limits in Public Drug Formularies on Provincial Costs Across Canada 2016 Diabetes
High-Dose Opioid Prescribing and Opioid-Related Hospitalization: A Population-Based Study 2016 Opioids Infographic Research Minute
Association of a Blood Glucose Test Strip Quantity-Limit Policy With Patient Outcomes: A Population-Based Study 2016 Diabetes Infographic Research Minute
Varenicline and risk of self-harm: A nested case-control study 2016 Drug Safety and Efficacy
The appropriateness and persistence of testosterone replacement therapy in Ontario 2016 Drug Adherence
Persistence of antipsychotic treatment in elderly dementia patients 2016 Drug Adherence
Trends in the use and cost of antipsychotics among older adults from 2007-2013 2016 Drug Utilization
Interprovincial variation in antipsychotic and antidepressant prescription dispensed in the Canadian pediatric population 2016 Drug Utilization
Self-monitoring of blood glucose levels: evaluating the impact of a policy of quantity limits on test-strip use and costs 2016 Diabetes Policy Research Minute
Off-label use of inhaled tobramycin in Ontario Canada 2016 Adherence to prescribing standards  Policy Research Minute
The characteristics of treated pulmonary arterial hypertension patients in Ontario 2016 Cardiovascular Health
Novel oral anticoagulants and the risk of major hemorrhage in elderly patients with chronic kidney disease 2016 Cardiovascular Health Clinical Research Minute
Variations in costs and use of provincially-funded testosterone replacement therapy across Canada 2016 DCR: TRT Drug Class Review Findings
Factors that may be influencing the rise in prescription testosterone replacement therapy in adult men: a qualitative study 2016 DCR: TRT Drug Class Review Findings
The influence of socioeconomic status on selection of anticoagulation for atrial fibrillation 2016 Cardiovascular Health
Comparative safety and effectiveness of long-acting inhaled agents for treating COPD: a systematic review and network meta-analysis 2015 Respiratory Review Drug Class Review Findings
Professional pharmacy services and patient complexity: an observational study 2015 Drug Efficacy and Safety Policy Research Minute
Sensitivity and specificity of administrative mortality data for identifying prescription opioid-related deaths 2015  Opioids
Trends in the co-prescription of proton pump inhibitors with clopidogrel: an ecological analysis 2015 Cardiovascular Health
Evaluating the effectiveness of first-time methadone maintenance therapy across northern rural and urban regions of Ontario 2015 Opioids Policy Research Minute
Ticagrelor and bradycardia: a nested case-control study 2015 Drug Efficacy and Safety
Sex differences in dose escalation and overdose death during chronic opioid therapy: a population-based cohort study 2015 Opioids Policy Research Minute Clinical Research Minute Patient Research Minute
The impact of policies to reduce blood glucose test strip utilization and costs in Canada 2015 Diabetes Policy Research Minute
Access to Triptans for Acute Episodic Migraine: A Qualitative Study 2015 DCR: Triptans Drug Class Review Findings
Triptans for Acute Migraine: A Drug Class Review to Help Inform Policy Decisions 2015 DCR: Triptans Drug Class Review Findings
Public Drug Coverage and Its Impact on Triptan Use Across Canada: A Population-Based Study 2015 DCR: Triptans Drug Class Review Findings
Triptans in the Acute Treatment of Migraine: A Systematic Review and Network Meta-Analysis 2015 DCR: Triptans Drug Class Review Findings
Reimbursement-Based Economics – What Is It and How Can We Use it to Inform Drug Policy Reform? 2015 DCR: Triptans Drug Class Review Findings
Safety of valproic acid in patients with chronic obstructive pulmonary disease:  a population-based cohort study 2015 Drug Efficacy and Safety
Rates of ischemic stroke during warfarin treatment for atrial fibrillation 2015 Drug Efficacy and Safety
Neonatal opioid withdrawal and antenatal opioid prescribing 2015 Opioids Policy Research Minute Clinical Research Minute
Impact of legislation and a prescription monitoring program on the prevalence of potentially inappropriate prescriptions for monitored drugs in Ontario 2014 Opioids Policy Research Minute Clinical Research Minute
Trends in high-dose opioid prescribing in Canada 2014 Opioids Policy Research Minute
Adverse cardiac events in older patients receiving venlafaxine: a population-based study 2014 Cardiovascular Health
The Ontario Drug Policy Research Network: Bridging the gap between Research and Drug Policy 2014 Research and policy outcomes
The impact of drug reimbursement policy on rates of testosterone replacement therapy among older men 2014 Testosterone replacement therapy Policy Research Minute Clinical Research Minute Patient Research Minute
The burden of premature opioid-related mortality 2014 Opioids Policy Research Minute Clinical Research Minute Research Minute Manuscript Public Report
Adherence to prescribing recommendations made on a provincial formulary 2014 Adherence to prescribing standards Policy Research Minute Clinical Research Minute
Upper gastrointestinal bleeding in elderly patients with dementia receiving cholinesterase inhibitors: a population-based cohort study 2014 Adverse Events Clinical Research Minute
Statins and the risk of herpes zoster: a population-based cohort study 2014 Statins
Trends in selection and timing of first-line pharmacotherapy in older patients with type 2 diabetes diagnosed between 1994 and 2006 2013 Diabetes
Impact of the JUPITER trial on statin prescribing for primary prevention 2014 Statins
Hospitalization for hemorrhage among warfarin recipients prescribed amiodarone 2013 Drug-Drug Interactions
Comparative effectiveness of angiotensin-receptor blockers for preventing macrovascular disease in patients with diabetes: a population-based cohort study 2013 Diabetes Clinical Research Minute Patient Research Minute
Risk of incident diabetes among patients treated with statins: population based study 2013 Diabetes Clinical Research Minute Patient Research Minute
Effect of a course-based intervention and effect of medical regulation on physicians' opioid prescribing 2013 Opioids Policy Research Minute Clinical Research Minute
No increase in adverse events during aliskiren use among Ontario patients receiving angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers 2013 Drug-drug interactions
Rates of hemorrhage during warfarin therapy for atrial fibrillation 2013 Drug Efficacy and Safety
Chlorthalidone Versus Hydrochlorothiazide for the Treatment of Hypertension in Older Adults: A Population-Based Cohort Study 2013 Hypertension
Progression through diabetes therapies among new elderly users of metformin: a population-based study 2013 Diabetes
Risk of acute kidney injury from oral acyclovir: a population-based study 2013 Drug Efficacy and Safety
Opioid dose and risk of road trauma in Canada: a population-based study 2013 Opioid Policy Research Minute Clinical Research Minutes Patient Research Minute
Multiple sclerosis disease-modifying therapy prescribing patterns in Ontario 2013 Multiple Sclerosis
Antidepressant use serotonin transporter affinity and reinfarction among patients receiving clopidogrel: a population-based study 2012 Cardiovascular Health
Adverse cardiovascular events during treatment with glyburide (glibenclamide) or gliclazide in a high-risk population 2012 Drug Efficacy and Safety Patient Research Minute
Persistence with therapy among patients treated with warfarin for atrial fibrillation 2012 Drug Adherence
Reformulation of controlled-release oxycodone and pharmacy dispensing patterns near the US–Canada border 2012 Opioids Policy Research Minute Clinical Research Minute
Oral bisphosphonate use in the elderly is not associated with acute kidney injury 2012 Adverse Events
Long-term Analgesic Use: Sometimes Less Is Not More—Reply 2012 Opioids
Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: A retrospective cohort study 2012 Opioids
Use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and cardiovascular outcomes in chronic dialysis patients: a population-based cohort study 2012 Cardiovascular Health
New Fibrate Use and Acute Renal Outcomes in Elderly Adults: A Population-Based Study 2012 Kidney Disease Clinical Research Minute Patient Research Minute
Antidepressants metoprolol and the risk of bradycardia 2012 Adverse Events
Selective serotonin reuptake inhibitors and pulmonary arterial hypertension: a case-control study 2012 Hypertension
Opioids versus nonsteroidal anti-inflammatory drugs in noncancer pain 2012 Opioids
Comparative adherence to oxybutynin or tolterodine among older patients 2012 Drug Adherence
Use of other opioids during methadone therapy: a population-based study 2012 Opioids
Beta-blockers and cardiovascular outcomes in dialysis patients: a cohort study in Ontario Canada 2011 Kidney Disease
Does orlistat cause acute kidney injury? 2011 Adverse Events
Effects of funding policy changes and health warnings on the use of erythropoiesis-stimulating agents 2012 Research and Policy Outcomes
Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study 2011 Adverse Events
Ciprofloxacin-induced theophylline toxicity: a population-based study 2011 Adverse Events
Clustering of opioid prescribing and opioid-related mortality among family physicians in Ontario 2011 Opioids
Trends in opioid use and dosing among socio-economically disadvantaged patients 2011 Opioids
Risk of serious falls associated with oxybutynin and tolterodine: A population based study 2011 Drug Efficacy and Safety
Geographical variation in opioid prescribing and opioid-related mortality in ontario 2011 Opioids Policy Research Minute Clinical Research Minute Public Report
The impact of federal warnings on publically funded desmopressin utilization among children in Ontario 2012 Research and Policy Outcomes
Opioid dose and drug-related mortality in patients with nonmalignant pain 2011 Opioids
The safety of proton pump inhibitors and clopidogrel in patients after stroke 2011 Adverse Events Policy Research Minute Clinical Research Minute Patient Research Minute
Hospital admissions for hyperkalemia with trimethoprim-sulfamethoxazole: A cohort study using health care database codes for 393 039 older women with urinary tract infections 2011 Adverse Events
Orlistat and acute kidney injury: an analysis of 953 patients 2011 Kidney Disease
Sevelamer prescriptions after reporting of the dialysis clinical outcomes revisited (DCOR) trial findings: An analysis of 5 495 patients receiving 2011 Kidney Disease
Adherence to multiple sclerosis disease-modifying therapies in Ontario is low 2011 Multiple Sclerosis
The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers 2011 Cardiovascular Health
Trimethoprim-sulfamethoxazole–induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system 2010 Adverse Events
Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study 2011 Adverse Events
Blood glucose test strips: options to reduce usage 2010 Diabetes Investigative Report
Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study 2009 Adverse Events  Policy Research Minute Clinical Research Minute Patient Research Minute
Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study 2010 Adverse Events
Cost and minimal effectiveness of SMBG 2010 Diabetes
Impaired renal function modifies the risk of severe hypoglycaemia among users of insulin but not glyburide: a population-based nested case–control study 2010 Kidney Disease
Beta-blockers trimethoprim-sulfamethoxazole and the risk of hyperkalemia requiring hospitalization in the elderly: A nested case-control study 2010 Adverse Events
Clinical and demographic characteristics of patients receiving different oral hypoglycemic agents 2009 Diabetes
Macrolide-induced digoxin toxicity: A population-based Study 2009 Adverse Events
ICES Report: new findings highlight potential risks of common drug combination in cardiac patients 2009 Drug-Drug Interactions

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