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Ranking: 2013 SJR (SCImago Journal Rank) Score: 0.553 | 112/247 Pharmacology (Medical) (Scopus®) | Indexed in PubMed and PubMed Central

Does orlistat cause acute kidney injury?

  1. Michael M Beyea m.beyea@utoronto.ca
    1. University of Western Ontario, Kidney Clinical Research Unit, London, Ontario, Canada
  2. Amit X Garg amit.garg@lhsc.on.ca
    1. University of Western Ontario, Kidney Clinical Research Unit/Dept of Med, Div. of Nephrology/Institute for Clinical Evaluative Sciences, Toronto Ontario Canada
  3. Matthew A Weir matthew.weir@lhsc.on.ca
    1. ALL-139A, University Hospital, London, Ontario, Canada


Orlistat is an inhibitor of gastric and pancreatic lipase with proven efficacy in the augmentation and maintenance of weight loss. Although its use has been limited by troublesome but benign gastrointestinal side effects, it has more recently been associated with acute kidney injury (AKI). In this review, we summarize orlistat’s benefits and drawbacks and discuss the body of evidence supporting its role as a cause of AKI. Although we cannot yet draw an unequivocal causal link between orlistat and AKI, there is enough evidence to include orlistat exposure in the clinical assessment of patients with AKI.

This Article

  1. Therapeutic Advances in Drug Safety 2042098611429985
    All Versions of this Article:
    1. Version of Record - Mar 22, 2012
    2. current version image indicatorOnlineFirst Version of Record - Nov 23, 2011
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