Drug Safety and Effectiveness

Pharmacovigilance research is imperative in informing better pharmaceutical practice, policy and treatment related to drug safety and effectiveness. The ODPRN has conducted multiple studies evaluating the real-world comparative effectiveness of drug therapies, drug-drug interactions, and potential adverse events associated with numerous drugs.

All Research on Drug Safety and Effectiveness

wdt_ID Title Publication Type Date Released Clinical Topic Additional Resources
wdt_ID Title Publication Type Date Released Clinical Topic Additional Resources
1 ICES Report: New findings highlight potential risks of common drug combination in cardiac patients Journal Article 01 May 2009 Cardiovascular Health
2 Macrolide-induced digoxin toxicity: A population-based study Journal Article 15 Jul 2009 Cardiovascular Health
3 Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: Population based cohort study Journal Article 19 Aug 2009 Diabetes Research Minute
4 Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone Journal Article 07 Dec 2009 Opioids Letter to Editor
5 Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: A population based cohort study Journal Article 09 Feb 2010 Other
6 Trimethoprim-sulfamethoxazole–induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system Journal Article 28 Jun 2010 Cardiovascular Health
7 Beta-blockers trimethoprim-sulfamethoxazole and the risk of hyperkalemia requiring hospitalization in the elderly: A nested case-control study Journal Article 01 Sep 2010 Cardiovascular Health
8 Impaired renal function modifies the risk of severe hypoglycaemia among users of insulin but not glyburide: A population-based nested case-control study Journal Article 25 Oct 2010 Kidney Disease
9 The safety of proton pump inhibitors and clopidogrel in patients after stroke Journal Article 27 Dec 2010 Cardiovascular Health Research Minute
10 Hospital admissions for hyperkalemia with trimethoprim-sulfamethoxazole: A cohort study using health care database codes for 393 039 older women with urinary tract infections Letter to Editor 08 Jan 2011 Kidney Disease
11 Ciprofloxacin-induced theophylline toxicity: A population-based study Journal Article 14 Jan 2011 Cardiovascular Health
12 The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers Journal Article 22 Feb 2011 Cardiovascular Health
13 Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: A population-based study Journal Article 11 Mar 2011 Other
14 Orlistat and acute kidney injury: an analysis of 953 patients Journal Article 11 Apr 2011 Kidney Disease
15 Opioid dose and drug-related mortality in patients with nonmalignant pain Journal Article 11 Apr 2011 Opioids
16 Risk of serious falls associated with oxybutynin and tolterodine: a population based study Journal Article 18 Aug 2011 Overactive Bladder
17 Beta-blockers and cardiovascular outcomes in dialysis patients: A cohort study in Ontario, Canada Journal Article 26 Aug 2011 Kidney Disease
18 Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: Nested case-control study Journal Article 12 Sep 2011 Cardiovascular Health
19 Selective serotonin reuptake inhibitors and pulmonary arterial hypertension: A case-control study Journal Article 01 Feb 2012 Cardiovascular Health
20 Antidepressants, metoprolol and the risk of bradycardia Journal Article 01 Apr 2012 Mental Health
21 Use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and cardiovascular outcomes in chronic dialysis patients: A population-based cohort study Journal Article 09 Apr 2012 Kidney Disease
22 New fibrate use and acute renal outcomes in elderly adults: A population-based study Journal Article 17 Apr 2012 Kidney Disease Research Minute
23 Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: A retrospective cohort study Journal Article 27 Apr 2012 Opioids
24 Oral bisphosphonate use in the elderly is not associated with acute kidney injury Journal Article 13 Jun 2012 Kidney Disease
25 Antidepressant use, serotonin transporter affinity, and reinfarction among patients receiving clopidogrel: A population-based study Journal Article 22 Oct 2012 Cardiovascular Health
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